Aflatoxin B1 exposure induced developmental toxicity and inhibited muscle development in zebrafish embryos and larvae

XN He, P Wu, WD Jiang, Y Liu, SY Kuang… - Science of the total …, 2023 - Elsevier
The prevalence of aflatoxin B1 (AFB1), one of the most toxic mycotoxins that contaminates
feedstock and food is increasing worldwide. AFB1 can cause various health problems in …

[HTML][HTML] Porcine β-defensin-2 alleviates AFB1-induced intestinal mucosal injury by inhibiting oxidative stress and apoptosis

X Jin, Q Li, J Sun, M Zhang, Y Xiang - Ecotoxicology and Environmental …, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is the most toxic mycotoxin contaminant, which is widely
present in crops and poses a major safety hazard to animal and human health. To alleviate …

Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

E Ofori-Attah, M Hashimoto, M Oki… - International Journal of …, 2024 - mdpi.com
Aflatoxins are harmful natural contaminants found in foods and are known to be hepatotoxic.
However, recent studies have linked chronic consumption of aflatoxins to nephrotoxicity in …

[HTML][HTML] SeMet alleviates AFB1-induced oxidative stress and apoptosis in rabbit kidney by regulating Nrf2//Keap1/NQO1 and PI3K/AKT signaling pathways

Y Liu, J Wang, Z Chang, S Li, Z Zhang, S Liu… - Ecotoxicology and …, 2024 - Elsevier
The purpose of this study was to explore the protective effect of SeMet on renal injury
induced by AFB 1 in rabbits and its molecular mechanism. Forty rabbits of 35 days old were …

Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation

SE Owumi, GE Adebisi, OA Odunola - Chemico-Biological Interactions, 2023 - Elsevier
Abstract The “anthracycline, Epirubicin (EPI),” in managing breast cancer, is highly cytotoxic.
Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its …

Modulation of the Nrf-2 and HO-1 signalling axis is associated with Betaine's abatement of fluoride-induced hepatorenal toxicities in rats

S Owumi, H Agbarogi, BJ Oluwawibe… - Naunyn-Schmiedeberg's …, 2024 - Springer
Sodium fluoride (NaF) ingestion has several detrimental effects in humans and rodents. NaF
mechanisms of toxicity include perturbation of intracellular redox homeostasis and …

Response of broilers to dietary inclusion of atoxigenic Aspergillus flavus strain as a biocontrol strategy of aflatoxin

AO Salako, JO Atteh, TO Akande, IO Kolade… - Avian …, 2024 - Taylor & Francis
The objective of this trial was to evaluate how broilers responded to Aspergillus flavus
strains that are toxigenic and atoxigenic. The study included four treatments in a 2× 2 …

[HTML][HTML] Metabolomics analysis reveals a protective effect of hydroxycitric acid on calcium oxalate-induced kidney injury

P Cao, Y Li, Z Zhang - Iranian Journal of Basic Medical …, 2024 - pmc.ncbi.nlm.nih.gov
Objective (s): Prior research has indicated that hydroxycitric acid (HCA) can impede the
formation of calcium oxalate (CaOx) crystals, yet the specific mechanisms underlying its …

Epirubicin Treatment Induces Neurobehavioral, Oxido-Inflammatory and Neurohistology Alterations in Rats: Protective Effect of the Endogenous Metabolite of …

SE Owumi, G Adebisi - Neurochemical Research, 2023 - Springer
Epirubicin's (EPI) efficacy as a chemotherapeutic agent against breast cancer is limited by
EPI's neurotoxicity associated with increased oxidative and inflammatory stressors. 3 …