Visual system circuitry, a canonical model system for the study of experience-dependent
development, matures before and following the onset of vision. Sensory experience or …

Blindness often results in the adaptive neural reorganization of the remaining modalities,
producing sharper auditory and haptic behavioral performance. Yet, non-visual modalities …

Sensory experience and spontaneous activity play important roles in development of
sensory circuits; however, their relative contributions are unclear. Here, we test the role of …

The mouse is a promising model in the study of visual system function and development
because of available genetic tools. However, a quantitative analysis of visual receptive field …

Applying a synthesis procedure that promotes alloy formation, highly-dispersed alumina-
supported Pt–Pd catalysts spanning the Pt-rich half of the composition range were prepared …

Highlights•Molecular cues and activity together shape visual circuit development.•Activity
influences development at all levels of the visual system.•Before vision, activity is generated …

In the mammalian visual system, sensory experience is widely thought to sculpt cortical
circuits during a precise critical period. In contrast, subcortical regions, such as the thalamus …

It is well established that spontaneous activity in the developing mammalian brain plays a
fundamental role in setting up the precise connectivity found in mature sensory circuits …

The development and connectivity of retinal ganglion cells (RGCs), the retina's sole output
neurons, are patterned by activity-independent transcriptional programs and activity …

It is commonly believed that the ability to integrate information from different senses
develops according to associative learning principles as neurons acquire experience with …