Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Macrophages: the good, the bad, and the gluttony
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …
sterile inflammation. In this review, we will compile and interpret recent findings on the …
NF‐κB signaling in inflammation and cancer
T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …
in 1986, extraordinary efforts have been made to understand the function and regulating …
Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis
YJ Lin, M Anzaghe, S Schülke - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …
[HTML][HTML] Epstein-Barr virus and systemic autoimmune diseases
G Houen, NH Trier - Frontiers in immunology, 2021 - frontiersin.org
Epstein-Barr Virus (EBV) is an extremely successful human herpes virus, which infects
essentially all human beings at some time during their life span. EBV infection and the …
essentially all human beings at some time during their life span. EBV infection and the …
Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies
AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …
progressive autoimmune disease affecting many people worldwide. While patients show …
[HTML][HTML] Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment
L Zhang, Z Qin, H Sun, X Chen, J Dong, S Shen… - Bioactive materials, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and
destruction of cartilage, promoted by sustained inflammation. However, current treatments …
destruction of cartilage, promoted by sustained inflammation. However, current treatments …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
[HTML][HTML] Disease modifying anti-rheumatic drugs (DMARD)
O Benjamin, A Goyal, SL Lappin - 2018 - europepmc.org
Objectives: Explain the difference between traditional and biological DMARDs. Identify the
indications for various DMARD agents. Outline the adverse effects and contraindications to …
indications for various DMARD agents. Outline the adverse effects and contraindications to …
Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999–2018
L Chen, Q Sun, S Peng, T Tan, G Mei, H Chen, Y Zhao… - Chemosphere, 2022 - Elsevier
Heavy metals exposure has been widely recognized as a risk factor for human health.
However, limited information is available about the impacts of heavy metals on rheumatoid …
However, limited information is available about the impacts of heavy metals on rheumatoid …