This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Background Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated
in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator …

Background There is increasing support for the hypothesis that gonadal steroids involved in
the regulation of the human menstrual cycle modulate γ-aminobutyric acid (GABA) neuronal …

BACKGROUND: Alterations in the γ-amino-butyric acid (GABA) neurotransmitter system
have been identified in some populations with posttraumatic stress disorder (PTSD) …

Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms
are obscure. Here, we provide evidence that GABAA receptor-modulating neurosteroids …

Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …

Aging is a general process of functional decline which involves in particular a decline of
cognitive abilities. However, the severity of this decline differs from one subject to another …

The hypothalamo–pituitary–adrenal (HPA) axis plays a key role in the neuroendocrine
response to stress and in maintaining physiological homoeostasis. However, stress that is …

The progesterone metabolite allopregnanolone (3α-OH-5α-pregnane-20-one) inhibits
neural functions, enhancing the GABA induced GABAA receptor activation. This effect is …