Neurosteroids: endogenous role in the human brain and therapeutic potentials
DS Reddy - Progress in brain research, 2010 - Elsevier
This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
[HTML][HTML] Trial of SAGE-217 in patients with major depressive disorder
H Gunduz-Bruce, C Silber, I Kaul… - … England Journal of …, 2019 - Mass Medical Soc
Background Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated
in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator …
in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator …
Cortical γ-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance …
CN Epperson, K Haga, GF Mason… - Archives of general …, 2002 - jamanetwork.com
Background There is increasing support for the hypothesis that gonadal steroids involved in
the regulation of the human menstrual cycle modulate γ-aminobutyric acid (GABA) neuronal …
the regulation of the human menstrual cycle modulate γ-aminobutyric acid (GABA) neuronal …
Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder
AM Rasmusson, G Pinna, P Paliwal, D Weisman… - Biological …, 2006 - Elsevier
BACKGROUND: Alterations in the γ-amino-butyric acid (GABA) neurotransmitter system
have been identified in some populations with posttraumatic stress disorder (PTSD) …
have been identified in some populations with posttraumatic stress disorder (PTSD) …
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABAA receptor function and seizure susceptibility
DS Reddy, MA Rogawski - Journal of Neuroscience, 2002 - Soc Neuroscience
Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms
are obscure. Here, we provide evidence that GABAA receptor-modulating neurosteroids …
are obscure. Here, we provide evidence that GABAA receptor-modulating neurosteroids …
Neurosteroids, stress and depression: potential therapeutic opportunities
Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging
M Vallée, W Mayo, M Le Moal - Brain Research Reviews, 2001 - Elsevier
Aging is a general process of functional decline which involves in particular a decline of
cognitive abilities. However, the severity of this decline differs from one subject to another …
cognitive abilities. However, the severity of this decline differs from one subject to another …
Sex, stress and steroids
Y Sze, PJ Brunton - European Journal of Neuroscience, 2020 - Wiley Online Library
The hypothalamo–pituitary–adrenal (HPA) axis plays a key role in the neuroendocrine
response to stress and in maintaining physiological homoeostasis. However, stress that is …
response to stress and in maintaining physiological homoeostasis. However, stress that is …
Allopregnanolone inhibits learning in the Morris water maze
IM Johansson, V Birzniece, C Lindblad, T Olsson… - Brain research, 2002 - Elsevier
The progesterone metabolite allopregnanolone (3α-OH-5α-pregnane-20-one) inhibits
neural functions, enhancing the GABA induced GABAA receptor activation. This effect is …
neural functions, enhancing the GABA induced GABAA receptor activation. This effect is …