Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein
degradation tool developed in recent years that can ubiquitinate the target proteins through …

Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …

The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …

The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …

Indazole-containing derivatives represent one of the most important heterocycles in drug
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …

Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely
used strategy for treating malignant tumors. However, most intracellular proteins have been …

The visible light harnessing ability of Rose Bengal, an organic dye, has been extensively
employed in organic chemistry over the last few years. In visible light mediated reactions …

With different nitrogen‐containing heterocyclic moieties, Indazoles earn one of the places
among the top investigated molecules in medicinal research. Indazole, an important fused …

Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

Herein, the C3–H alkylation of 2 H-indazoles and indoles with sulfoxonium ylides is
developed under visible-light photocatalysis. This protocol employs easily accessible …