Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Telomere maintenance by telomerase activation or alternative lengthening of telomeres
(ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in …

ABSTRACT Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification
that is best known for its role in constitutive heterochromatin formation and the repression of …

Gene silencing by heterochromatin plays a crucial role in cell identity. Here, we characterize
the localization, the biogenesis, and the function of an atypical heterochromatin, which is …

Epigenetic regulation of gene expression has been ultimately linked to cancer development,
with posttranslational histone modifications representing attractive targets for disease …

Decades of study on cell cycle regulation have provided great insight into human cellular life
span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the …

TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …