Long noncoding RNA in cancer: wiring signaling circuitry

C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …

[HTML][HTML] Human long noncoding RNA interactome: detection, characterization and function

M Kazimierczyk, MK Kasprowicz, ME Kasprzyk… - International journal of …, 2020 - mdpi.com
The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

CRISPR/Cas9‐mediated mutagenesis of lncRNA1459 alters tomato fruit ripening

R Li, D Fu, B Zhu, Y Luo, H Zhu - The Plant Journal, 2018 - Wiley Online Library
With the development of high‐throughput sequencing, many long non‐coding RNA s (lnc
RNA s) have been found to play important roles in diverse biological processes. However …

[HTML][HTML] Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

L Zhang, X Meng, X Zhu, D Yang, R Chen, Y Jiang… - Molecular cancer, 2019 - Springer
There is growing evidence that regions of the genome that cannot encode proteins play an
important role in diseases. These regions are usually transcribed into long non-coding …

Protein–DNA/RNA interactions: an overview of investigation methods in the-omics era

F Cozzolino, I Iacobucci, V Monaco… - Journal of Proteome …, 2021 - ACS Publications
The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

LncADeep: an ab initio lncRNA identification and functional annotation tool based on deep learning

C Yang, L Yang, M Zhou, H Xie, C Zhang… - …, 2018 - academic.oup.com
Motivation To characterize long non-coding RNAs (lncRNAs), both identifying and
functionally annotating them are essential to be addressed. Moreover, a comprehensive …

From structure to function: Route to understanding lncRNA mechanism

J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …

Noncoding RNAs in neurodegeneration

E Salta, B De Strooper - Nature Reviews Neuroscience, 2017 - nature.com
The emerging complexity of the transcriptional landscape poses great challenges to our
conventional preconceptions of how the genome regulates brain function and dysfunction …

Emerging roles of long non-coding RNAs in plant response to biotic and abiotic stresses

N Nejat, N Mantri - Critical reviews in biotechnology, 2018 - Taylor & Francis
Spectacular progress in high-throughput transcriptome sequencing and expression profiling
using next-generation sequencing technologies have recently revolutionized molecular …

[HTML][HTML] Long noncoding RNA functionality in imprinted domain regulation

WA MacDonald, MRW Mann - PLoS Genetics, 2020 - journals.plos.org
Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …