Abstract Aim The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure”
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …

Abstract Aim The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure”
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy
caused by extracellular deposition of transthyretin, normally involved in the transportation of …

Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to
progressive organ failure. There are over 15 types of systemic amyloidosis, each caused by …

Technetium-labeled cardiac scintigraphy (ie, Tc-PYP scan) has been repurposed for the
diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM). Validated in cohorts of …

Importance Many patients with systemic amyloidosis are underdiagnosed. Overall, 25% of
patients with immunoglobulin light chain (AL) amyloidosis die within 6 months of diagnosis …

Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal
significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for …

Amyloid light chain (AL) amyloidosis is among the more common and more severe of the
amyloidoses usually involving the slow proliferation of a bone-marrow-residing plasma cell …

Amyloidosis is a group of complex diseases caused by extracellular deposition of
pathological insoluble fibrillary protein in organs and tissues and may result in severe organ …