Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after
brain ischemia, but the underlying mechanism remains poorly understood. Here, we …

SUMOylation is an essential modification that regulates hundreds of proteins in eukaryotic
cells. Owing to its dynamic nature and low steady-state levels, endogenous SUMOylation is …

Global increases in small ubiquitin‐like modifier (SUMO)‐2/3 conjugation are a
neuroprotective response to severe stress but the mechanisms and specific target proteins …

Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Insights into the evolution of non-model organisms are limited by the lack of reference
genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome …

Protein aggregation critically affects cell viability in neurodegenerative diseases, but
whether this also occurs in ischemic brain injury remains elusive. Prior studies report the …

Oxygen is essential for viability in mammalian organisms. However, cells are often exposed
to changes in oxygen availability, due to either increased demand or reduced oxygen …

Recent data indicates that DJ-1 plays a role in the cellular response to stress. Here, we
aimed to examine the underlying molecular mechanisms mediating the actions of DJ-1 in …