Does ceruloplasmin defend against neurodegenerative diseases?

B Wang, XP Wang - Current neuropharmacology, 2019 - ingentaconnect.com
Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the
liver. Glycosylphosphatidylinositol-linked CP (GPI-CP) is the predominant form expressed in …

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

V Gupta, VB Gupta, N Chitranshi, S Gangoda… - Cellular and molecular …, 2016 - Springer
Accumulation of amyloid β (Aβ) and its aggregates in the ageing central nervous system is
regarded synonymous to Alzheimer's disease (AD) pathology. Despite unquestionable …

Quinoline fluorescent probes for zinc–from diagnostic to therapeutic molecules in treating neurodegenerative diseases

B Czaplinska, E Spaczynska, R Musiol - Medicinal Chemistry, 2018 - ingentaconnect.com
Background: Fluorescent compounds had gained strong attention due to their wide and
appealing applications. Microscopic techniques and visualization are good examples …

Targeting the zinc transporter ZIP7 in the treatment of insulin resistance and type 2 diabetes

J Adulcikas, S Sonda, S Norouzi, SS Sohal, S Myers - Nutrients, 2019 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic
processes that lead to abnormally high levels of blood glucose. Preceding the development …

Association between serum ceruloplasmin specific activity and risk of Alzheimer's disease

M Siotto, I Simonelli, P Pasqualetti… - Journal of …, 2016 - content.iospress.com
Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the
systemic ceruloplasmin status in relation to copper is an emerging issue. To deepen this …

[HTML][HTML] Copper metabolism and its role in diabetic complications: A review

D Jia, L Liu, W Liu, J Li, X Jiang, Y Xin - Pharmacological Research, 2024 - Elsevier
Disturbances in copper (Cu) homeostasis have been observed in diabetes and associated
complications. Cu is an essential micronutrient that plays important roles in various …

Novel perspective on Alzheimer's disease treatment: Rosmarinic acid molecular interplay with copper (II) and amyloid β

A Kola, A Hecel, S Lamponi, D Valensin - Life, 2020 - mdpi.com
Alzheimer's disease is a severe disorder that affects millions of people worldwide. It is a very
debilitating disease with no cure at the moment. The necessity of finding an effective …

Non-ceruloplasmin copper distincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency

R Squitti, M Ventriglia, M Gennarelli, NA Colabufo… - Molecular …, 2017 - Springer
Meta-analyses show that serum copper non-bound-to-ceruloplasmin (non-Cp-Cu) is higher
in patients with Alzheimer's disease (AD). ATP7B gene variants associate with AD …

The Efficacy and Pharmacological Mechanism of Zn7MT3 to Protect against Alzheimer's Disease

W Xu, Q Xu, H Cheng, X Tan - Scientific Reports, 2017 - nature.com
Alzheimer's disease (AD) is one of the leading causes of death for people over 65 years.
Worse still, no completely effective therapeutic agent is available so far. One important …

Ceruloplasmin: Its role in the physiological and pathological processes

VV Orzheshkovskyi, MA Trishchynska - Neurophysiology, 2019 - Springer
Literature data on the role of the copper-containing metalloprotein ceruloplasmin (CP) in
physiological and pathological processes, namely in health and in Wilson's disease and …