Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

NTIRE 2022 spectral demosaicing challenge and data set

B Arad, R Timofte, R Yahel, N Morag… - Proceedings of the …, 2022 - openaccess.thecvf.com
This paper presents the first challenge on demosaicing of natural spectral images for
snapshot hyperspectral imaging systems (HIS) which utilize a multi-spectral filer array …

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …

Label-free hyperspectral imaging and deep-learning prediction of retinal amyloid β-protein and phosphorylated tau

X Du, Y Koronyo, N Mirzaei, C Yang, DT Fuchs… - PNAS …, 2022 - academic.oup.com
Alzheimer's disease (AD) is a major risk for the aging population. The pathological hallmarks
of AD—an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau) …

Artificial intelligence in dementia

A Richardson, CB Robbins, CE Wisely… - Current Opinion in …, 2022 - journals.lww.com
Machine learning models that can accurately distinguish those with symptomatic Alzheimer's
dementia from those with mild cognitive impairment and normal cognition as well as predict …

Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial

OM Dumitrascu, J Doustar, DT Fuchs… - Acta Neuropathologica …, 2024 - Springer
The relationship between amyloidosis and vasculature in cognitive impairment and
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …

Multimodal retinal imaging to detect and understand Alzheimer's and Parkinson's disease

L Moons, L De Groef - Current opinion in neurobiology, 2022 - Elsevier
Retinal neurodegeneration and visual dysfunctions have been reported in a majority of
Alzheimer's and Parkinson's patients, and, in light of the quest for novel biomarkers for these …

Retinal imaging biomarkers of neurodegenerative diseases

E Christinaki, H Kulenovic, X Hadoux… - Clinical and …, 2022 - Taylor & Francis
The timely detection of neurodegenerative diseases is central to improving clinical care as
well as enabling the development and deployment of disease-modifying therapies. Retinal …