In the field of cancer genomics, the broad availability of genetic information offered by next-
generation sequencing technologies and rapid growth in biomedical publication has led to …

Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease involving hair
follicles that presents with painful nodules, abscesses, fistulae, and hypertrophic scars …

Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA) 4
and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there …

Data-driven discovery of cancer driver genes, including tumor suppressor genes (TSGs) and
oncogenes (OGs), is imperative for cancer prevention, diagnosis, and treatment. Although …

Deciphering the variations in the protein interactome is required to reach a systems-level
understanding of tumorigenesis. To accomplish this task, we have considered the clinical …

Background With the advent of CRISPR-Cas9 genome editing tool in gene therapy,
identification of aberrantly expressed genes is of great value across various cancer types …

The identification of cancer driver genes (CDGs) poses challenges due to the intricate
interdependencies among genes and the influence of measurement errors and noise. We …

The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to
their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines …

Extracranial germ cell tumors (GCT) are a biologically diverse group of tumors occurring in
children, adolescents, and young adults. The majority of patients have excellent outcomes …

Studies describing the expression patterns and biomarkers for the tumoral process increase
in number every year. The availability of new datasets, although essential, also creates a …