Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …

Background The promise of precision cancer medicine presently centers around the
genomic sequence of a patient's tumor being translated into timely, actionable information to …

Abstract The Oxford Nanopore (ONT) platform provides portable and rapid genome
sequencing, and its ability to natively profile DNA methylation without complex sample …

As hippocampal neurons respond to diverse types of information, a subset assembles into
microcircuits representing a memory. Those neurons typically undergo energy-intensive …

Castration-resistant prostate cancer (CRPC) is a heterogeneous disease associated with
phenotypic subtypes that drive therapy response and outcome differences. Histologic …

BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major
challenge in the management of patients undergoing hematopoietic stem cell …

Circulating cell-free DNA (cfDNA) fragments have characteristics that are specific to the cell
types that release them. Current methods for cfDNA deconvolution typically use disease …

Circulating cell-free DNA (cfDNA) fragments are a biological analyte with extensive utility in
diagnostic medicine. Understanding the source of cfDNA and mechanisms of release is …

Radiation therapy is an effective cancer treatment, although damage to healthy tissues is
common. Here we analyzed cell-free, methylated DNA released from dying cells into the …

Immune and inflammatory processes occurring within tissues are often undetectable by
blood cell counts, standard circulating biomarkers, or imaging, representing an unmet …