We review recent advances in our ability to characterise biomolecular structure, interactions
and associated dynamics by mass photometry (MP), the label-free detection and mass …

RNase P and RNase mitochondrial RNA processing (MRP) are ribonucleoproteins (RNPs)
that consist of a catalytic RNA and a varying number of protein cofactors. RNase P is …

tRNAs are typically transcribed with extended 5′ and 3′ ends that must be removed
before they attain their active form. One of the first steps of tRNA processing in nearly every …

Abstract tRNA genes are transcribed as precursors and RNase P generates the matured
5'end of tRNAs. It has been suggested that residue− 1 (the residue immediately 5ʹ of the …

Besides the canonical RNA-based RNase P, pre-tRNA 5'-end processing can also be
catalyzed by protein-only RNase P (PRORP). To date, various PRORPs have been …

Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA
precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an …

Label-free detection of single biomolecules in solution has been achieved using a variety of
experimental approaches over the past decade. Yet, our understanding of the magnitude of …

The endoribonuclease RNase P is responsible for tRNA 5′ maturation in all domains of life.
A unique feature of RNase P is the variety of enzyme architectures, ranging from dual-to …

A small group of bacteria encode two types of RNase P, the classical ribonucleoprotein
(RNP) RNase P as well as the protein-only RNase P HARP (h omolog of A quifex R Nase P) …

Ribonuclease P (RNase P) is an important ribonucleoprotein (RNP), responsible for the
maturation of the 5′ end of precursor tRNAs (pre-tRNAs). In all organisms, the cleavage …