The amazing potential of fungi: 50 ways we can exploit fungi industrially
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the
immense range of habitats that fungi inhabit, and the consequent need to compete against a …
immense range of habitats that fungi inhabit, and the consequent need to compete against a …
[HTML][HTML] Streptozotocin as a tool for induction of rat models of diabetes: A practical guide
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …
[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
A map of human type 1 diabetes progression by imaging mass cytometry
Summary Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-
producing β cells. A comprehensive picture of the changes during T1D development is …
producing β cells. A comprehensive picture of the changes during T1D development is …
Viral infections in type 1 diabetes mellitus—why the β cells?
A Op de Beeck, DL Eizirik - Nature Reviews Endocrinology, 2016 - nature.com
Type 1 diabetes mellitus (T1DM) is caused by progressive autoimmune-mediated loss of
pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors …
pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors …
Type 1 diabetes: etiology, immunology, and therapeutic strategies
TL Van Belle, KT Coppieters… - Physiological …, 2011 - journals.physiology.org
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
KT Coppieters, F Dotta, N Amirian… - Journal of Experimental …, 2012 - rupress.org
A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
F Thorel, V Népote, I Avril, K Kohno, R Desgraz… - Nature, 2010 - nature.com
Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …
Early prediction of autoimmune (type 1) diabetes
SE Regnell, Å Lernmark - Diabetologia, 2017 - Springer
Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
The pathogenesis and natural history of type 1 diabetes
MA Atkinson - Cold Spring Harbor perspectives …, 2012 - perspectivesinmedicine.cshlp.org
The purpose of this article is to provide an overview that summarizes much in the way of our
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …