CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Mammalian Hox gene clusters contain a range of CTCF binding sites. In addition to their
importance in organizing a TAD border, which isolates the most posterior genes from the …

The human genome is packaged within a three-dimensional (3D) nucleus and organized
into structural units known as compartments, topologically associating domains (TADs), and …

A rare form of X-linked Charcot-Marie-Tooth neuropathy, CMTX3, is caused by an
interchromosomal insertion occurring at chromosome Xq27. 1. Interestingly, eight other …

Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing
our evolutionary models. In this review, we consider the implications of new mechanistic …

Abstract X-linked acrogigantism (X-LAG) is the most severe form of pituitary gigantism and is
characterized by aggressive growth hormone (GH)-secreting pituitary tumors that occur in …

The contribution of deregulated chromatin architecture, including topologically associated
domains (TADs), to cancer progression remains ambiguous. CCCTC-binding factor (CTCF) …

In this review, we consider various aspects of enhancer functioning in the context of the 3D
genome. Particular attention is paid to the mechanisms of enhancer-promoter …

The human genome is folded into a multi-level 3D structure that controls many nuclear
functions including gene expression. Recently, alterations in 3D genome organization were …