Hallmarks of brain aging: adaptive and pathological modification by metabolic states
MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
Diagnostic and therapeutic potential of exosomes in Alzheimer's disease
T Soares Martins, D Trindade, M Vaz… - Journal of …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …
Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
M Sardar Sinha, A Ansell-Schultz, L Civitelli… - Acta …, 2018 - Springer
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate …
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate …
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …
now known to mediate physiological and pathological functions throughout the body. We …
Extracellular vesicles: multimodal envoys in neural maintenance and repair
MM Holm, J Kaiser, ME Schwab - Trends in Neurosciences, 2018 - cell.com
The physiology of the central nervous system (CNS) is built on a foundation of connection,
integration, and the exchange of complex information among brain cells. Emerging evidence …
integration, and the exchange of complex information among brain cells. Emerging evidence …
Biomarkers for Alzheimer's disease early diagnosis
E Ausó, V Gómez-Vicente, G Esquiva - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease
Synaptic dysfunction is an early mechanism in Alzheimer's disease that involves
progressively larger areas of the brain over time. However, how it starts and propagates is …
progressively larger areas of the brain over time. However, how it starts and propagates is …
Neuroimmune crosstalk through extracellular vesicles in health and disease
JC Delpech, S Herron, MB Botros, T Ikezu - Trends in neurosciences, 2019 - cell.com
The dynamics of CNS function rely upon omnidirectional communication among CNS cell
types. Extracellular vesicles (EVs) have emerged as key mediators of this communication …
types. Extracellular vesicles (EVs) have emerged as key mediators of this communication …
ISGylation–a key to lock the cell gates for preventing the spread of threats
C Villarroya-Beltri, S Guerra… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …
Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease
L Leggio, F L'Episcopo, A Magrì… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as powerful players in cell‐to‐cell communication
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …