Hallmarks of brain aging: adaptive and pathological modification by metabolic states

MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

T Soares Martins, D Trindade, M Vaz… - Journal of …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

M Sardar Sinha, A Ansell-Schultz, L Civitelli… - Acta …, 2018 - Springer
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate …

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology

AG Yates, RC Pink, U Erdbrügger… - Journal of …, 2022 - Wiley Online Library
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

Extracellular vesicles: multimodal envoys in neural maintenance and repair

MM Holm, J Kaiser, ME Schwab - Trends in Neurosciences, 2018 - cell.com
The physiology of the central nervous system (CNS) is built on a foundation of connection,
integration, and the exchange of complex information among brain cells. Emerging evidence …

Biomarkers for Alzheimer's disease early diagnosis

E Ausó, V Gómez-Vicente, G Esquiva - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …

Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease

M Gabrielli, I Prada, P Joshi, C Falcicchia, G D'Arrigo… - Brain, 2022 - academic.oup.com
Synaptic dysfunction is an early mechanism in Alzheimer's disease that involves
progressively larger areas of the brain over time. However, how it starts and propagates is …

Neuroimmune crosstalk through extracellular vesicles in health and disease

JC Delpech, S Herron, MB Botros, T Ikezu - Trends in neurosciences, 2019 - cell.com
The dynamics of CNS function rely upon omnidirectional communication among CNS cell
types. Extracellular vesicles (EVs) have emerged as key mediators of this communication …

ISGylation–a key to lock the cell gates for preventing the spread of threats

C Villarroya-Beltri, S Guerra… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …

Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease

L Leggio, F L'Episcopo, A Magrì… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as powerful players in cell‐to‐cell communication
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …