The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Study of the nematode Caenorhabditis elegans has provided important insights in a wide
range of fields in biology. The ability to precisely modify genomes is critical to fully realize …

The nascent polypeptide–associated complex (NAC) interacts with newly synthesized
proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) …

The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase
C (aPKC) form a core unit of the PAR protein network, which plays a central role in …

Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30
years ago, Borisy and White proposed that cortical flow converging upon the cell equator …

Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …

In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR)
polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of …

Correct spindle positioning is fundamental for proper cell division during development and
in stem cell lineages. Dynein and an evolutionarily conserved ternary complex (nuclear …

Although individuals age and die with time, an animal species can continue indefinitely,
because of its immortal germ-cell lineage. How the germline avoids transmitting damage …