Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Lung Cancer is the leading cause of cancer‐related deaths worldwide. This is mainly due to
late diagnosis and therefore advanced stage of the disease. Understanding the cell of origin …

A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …

SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …

Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical
adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally …

HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical
development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and developing therapies. Here, we review …

Lung cancer is the most common cancer and the leading cause of cancer-related death
worldwide. However, mechanisms of its progression remained unclear and new treatments …

Coordinated changes of cellular plasticity and identity are critical for pluripotent
reprogramming and oncogenic transformation. However, the sequences of events that …