The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is one of the most
deadly human cancers. The pathogenesis of HCC is frequently linked with continuous …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver surgery, including
liver resection, liver transplantation, and trauma surgery. Much has been learned about the …

Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …

TNF-α activates several intracellular pathways to regulate inflammation, cell death, and
proliferation. In the liver, TNF-α is not only a mediator of hepatotoxicity but also contributes to …

Recent genetic evidence has established a pathogenetic role for NF-κB signaling in cancer.
NF-κB signaling is engaged transiently when normal B lymphocytes respond to antigens, but …

The nuclear factor-κB (NF-κB) signalling pathway regulates immune responses and is
implicated in the pathogenesis of many inflammatory diseases. Given the well established …