Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Recent developments in catalytic amide bond formation

M Todorovic, DM Perrin - Peptide Science, 2020 - Wiley Online Library
Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

En route to a heterogeneous catalytic direct peptide bond formation by Zr-based metal–organic framework catalysts

F de Azambuja, A Loosen, D Conic… - Acs …, 2021 - ACS Publications
Peptide bond formation is a challenging, environmentally and economically demanding
transformation. Catalysis is key to circumvent current bottlenecks. To date, many …

How does silica catalyze the amide bond formation under dry conditions? Role of specific surface silanol pairs

A Rimola, M Fabbiani, M Sodupe, P Ugliengo… - ACS …, 2018 - ACS Publications
The mechanism of the amide bond formation between nonactivated carboxylic acids and
amines catalyzed by the surface of amorphous silica under dry conditions is elucidated by …

Microwave-assisted catalytic method for a green synthesis of amides directly from amines and carboxylic acids

AP Zarecki, JL Kolanowski, WT Markiewicz - Molecules, 2020 - mdpi.com
Amide bonds are among the most interesting and abundant molecules of life and products of
the chemical pharmaceutical industry. In this work, we describe a method of the direct …

Advances in homogeneous photocatalytic organic synthesis with colloidal quantum dots

DY Wang, YY Yin, CW Feng, YM Shen - Catalysts, 2021 - mdpi.com
Colloidal semiconductor quantum dots (QDs) have been proven to be excellent
photocatalysts due to their high photostability, large extinction coefficients, and tunable …

Lewis acidity quantification and catalytic activity of Ti, Zr and Al-supported mesoporous silica

MV Zakharova, F Kleitz, FG Fontaine - Dalton Transactions, 2017 - pubs.rsc.org
Water-tolerant supported Lewis acids are actively sought after, in particular to address the
challenging direct amidation reaction. To this aim, a versatile and easy synthesis of large …

[HTML][HTML] Heterogeneous catalytic direct amide bond formation

N Martin, FG Cirujano - Catalysis Communications, 2022 - Elsevier
The synthesis of amides by the direct reaction of carboxylic acids with amines is an
industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental …

Amidation of Carboxylic Acids with Amines by Nb2O5 as a Reusable Lewis Acid Catalyst

MA Ali, S Siddiki, W Onodera, K Kon… - ChemCatChem, 2015 - Wiley Online Library
Among 28 types of heterogeneous and homogenous catalysts tested, Nb2O5 shows the
highest yield for direct amidation of n‐dodecanoic acid with a less reactive amine (aniline) …

Nanostructured Carbon Catalyst for Amide Coupling Reactions under Microwave Heating in the Absence of a Solvent

D Pawelski, OF Delgado, AZ Wilczewska… - ACS Applied Nano …, 2022 - ACS Publications
Carbon nanostructures offer a perfect link between nanoscale materials and organic
molecules, making them an ideal platform for molecular catalysts. Herein, an efficient …