Green chemistry in the synthesis of pharmaceuticals
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
Recent developments in catalytic amide bond formation
M Todorovic, DM Perrin - Peptide Science, 2020 - Wiley Online Library
Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …
chemistry. Most current approaches for amidation employ stoichiometric activating agents …
En route to a heterogeneous catalytic direct peptide bond formation by Zr-based metal–organic framework catalysts
F de Azambuja, A Loosen, D Conic… - Acs …, 2021 - ACS Publications
Peptide bond formation is a challenging, environmentally and economically demanding
transformation. Catalysis is key to circumvent current bottlenecks. To date, many …
transformation. Catalysis is key to circumvent current bottlenecks. To date, many …
How does silica catalyze the amide bond formation under dry conditions? Role of specific surface silanol pairs
The mechanism of the amide bond formation between nonactivated carboxylic acids and
amines catalyzed by the surface of amorphous silica under dry conditions is elucidated by …
amines catalyzed by the surface of amorphous silica under dry conditions is elucidated by …
Microwave-assisted catalytic method for a green synthesis of amides directly from amines and carboxylic acids
AP Zarecki, JL Kolanowski, WT Markiewicz - Molecules, 2020 - mdpi.com
Amide bonds are among the most interesting and abundant molecules of life and products of
the chemical pharmaceutical industry. In this work, we describe a method of the direct …
the chemical pharmaceutical industry. In this work, we describe a method of the direct …
Advances in homogeneous photocatalytic organic synthesis with colloidal quantum dots
DY Wang, YY Yin, CW Feng, YM Shen - Catalysts, 2021 - mdpi.com
Colloidal semiconductor quantum dots (QDs) have been proven to be excellent
photocatalysts due to their high photostability, large extinction coefficients, and tunable …
photocatalysts due to their high photostability, large extinction coefficients, and tunable …
Lewis acidity quantification and catalytic activity of Ti, Zr and Al-supported mesoporous silica
MV Zakharova, F Kleitz, FG Fontaine - Dalton Transactions, 2017 - pubs.rsc.org
Water-tolerant supported Lewis acids are actively sought after, in particular to address the
challenging direct amidation reaction. To this aim, a versatile and easy synthesis of large …
challenging direct amidation reaction. To this aim, a versatile and easy synthesis of large …
[HTML][HTML] Heterogeneous catalytic direct amide bond formation
N Martin, FG Cirujano - Catalysis Communications, 2022 - Elsevier
The synthesis of amides by the direct reaction of carboxylic acids with amines is an
industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental …
industrially relevant reaction in fine chemistry and drug synthesis, as well as a fundamental …
Amidation of Carboxylic Acids with Amines by Nb2O5 as a Reusable Lewis Acid Catalyst
MA Ali, S Siddiki, W Onodera, K Kon… - ChemCatChem, 2015 - Wiley Online Library
Among 28 types of heterogeneous and homogenous catalysts tested, Nb2O5 shows the
highest yield for direct amidation of n‐dodecanoic acid with a less reactive amine (aniline) …
highest yield for direct amidation of n‐dodecanoic acid with a less reactive amine (aniline) …
Nanostructured Carbon Catalyst for Amide Coupling Reactions under Microwave Heating in the Absence of a Solvent
D Pawelski, OF Delgado, AZ Wilczewska… - ACS Applied Nano …, 2022 - ACS Publications
Carbon nanostructures offer a perfect link between nanoscale materials and organic
molecules, making them an ideal platform for molecular catalysts. Herein, an efficient …
molecules, making them an ideal platform for molecular catalysts. Herein, an efficient …