[HTML][HTML] The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery
AG Siraki - Redox biology, 2021 - Elsevier
This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader
the diversity of its presence in biology. The review provides a historical background, from …
the diversity of its presence in biology. The review provides a historical background, from …
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease
Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental
component of the innate immune response against microbial pathogens. In recent times …
component of the innate immune response against microbial pathogens. In recent times …
Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems
Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated
oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies …
oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies …
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: a new paradigm for drug discovery
Epidemiological results revealed that there is an inverse correlation between high-density
lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease …
lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease …
Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism
Drug metabolism is an essential process that chemically alters xenobiotic substrates to
activate or terminate drug activity. Myeloperoxidase (MPO) is a neutrophil-derived enzyme …
activate or terminate drug activity. Myeloperoxidase (MPO) is a neutrophil-derived enzyme …
Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents
The leukocyte-derived heme enzyme myeloperoxidase (MPO) is released extracellularly
during inflammation and impairs nitric oxide (NO) bioavailability by directly oxidizing NO or …
during inflammation and impairs nitric oxide (NO) bioavailability by directly oxidizing NO or …
Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation
H Eggleston, P Panizzi - Informatics, 2014 - mdpi.com
Molecular imaging by definition is the visualization of molecular and cellular processes
within a given system. The modalities and reagents described here represent a diverse …
within a given system. The modalities and reagents described here represent a diverse …
Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins
Kidney disease affects intestinal structure and function. Although intestinal lymphatics are
central in absorption and remodeling of dietary and synthesized lipids/lipoproteins, little is …
central in absorption and remodeling of dietary and synthesized lipids/lipoproteins, little is …
Reactive dicarbonyl scavenging effectively reduces MPO-mediated oxidation of HDL and restores PON1 activity
Atheroprotective functions of high-density lipoproteins (HDL) are related to the activity of
HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of …
HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of …
Peptide inhibitor of complement C1 inhibits the peroxidase activity of hemoglobin and myoglobin
PS Hair, KM Cunnion… - International Journal of …, 2017 - Wiley Online Library
Hemoglobin is the natural carrier of oxygen in red blood cells (RBCs). While intracellular
hemoglobin provides life‐sustaining oxygen transport, extracellular free hemoglobin …
hemoglobin provides life‐sustaining oxygen transport, extracellular free hemoglobin …