Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

The development of new drugs is multidisciplinary and systematic work. High-throughput
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …

ABSTRACT Background: Inhibitors targeting integrins (ITGs) are applied as a novel strategy
for cancers including lung cancer; however, the heterogeneity of ITG subunits might explain …

Abstract β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied
components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a low survival rate.
Recently, new drugs that target KRASG12D, a common mutation in PDAC, have been …

Objectives Recently, necroptosis has attracted increasing attention in arthritis research;
however, it remains unclear whether its regulation is involved in osteoarthritis (OA) …

Epithelial ovarian cancer involves the shedding of single tumor cells or spheroids from the
primary tumor into ascites, followed by their survival, and transit to the sites of metastatic …

Drug repositioning is an attractive alternative to conventional drug development when new
beneficial effects of old drugs are clinically validated because pharmacokinetic and safety …

Chemotherapy has substantially improved gastric cancer (GC) patient outcomes in the past
decades. However, the development of chemotherapy resistance has become the major …