In the past fifteen years, it has become apparent that tumour-associated p53 mutations can
provoke activities that are different to those resulting from simply loss of wild-type tumour …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Mutations in the TP53 (p53) gene are present in a large fraction of human tumours, which
frequently express mutant p53 proteins at high but heterogeneous levels. The clinical …

The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene.
Almost immediately it became clear that its major role is as a master regulator of tumor …

TAp73 is a structural homologue of the pre-eminent tumour suppressor p53. However,
unlike p53, TAp73 is rarely mutated, and instead is frequently overexpressed in human …

The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that
affect both cancer and development. It is now emerging that these proteins also regulate …