Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent
anxiety-like behaviors raises novel questions. One question is to determine whether OCN is …

The powerful regulation of bone mass exerted by the brain suggests the existence of bone-
derived signals modulating this regulation or other functions of the brain. We show here that …

The need to sleep grows with the duration of wakefulness and dissipates with time spent
asleep, a process called sleep homeostasis. What are the consequences of staying awake …

Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic
neurons but not expression of its receptor on these neurons. The same is true for its …

The past 20 years witnessed an enormous leap in understanding of the central regulation of
whole-body energy metabolism. Genetic tools have enabled identification of the region …

Neurobehavioral disorders are increasingly prevalent in children, however their etiology is
not well understood. An association between prenatal cellular telephone use and …

Why we sleep seems like a simple question, yet it has baffled scientists for generations.
Based on recent data, Emmanuel Mignot argues that the function of sleep is essentially a …