High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints

MA Lisio, L Fu, A Goyeneche, Z Gao… - International journal of …, 2019 - mdpi.com
Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

[HTML][HTML] Epidemiology of ovarian cancer: a review

BM Reid, JB Permuth, TA Sellers - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the
world and the tenth most common in China. Epithelial OC is the most predominant …

[HTML][HTML] ESMO–ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours …

N Colombo, C Sessa, A du Bois, J Ledermann… - Annals of oncology, 2019 - Elsevier
The development of guidelines recommendations is one of the core activities of the
European Society for Medical Oncology (ESMO) and European Society of Gynaecologial …

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

MA Eckert, F Coscia, A Chryplewicz, JW Chang… - Nature, 2019 - nature.com
High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …

High grade serous ovarian carcinomas originate in the fallopian tube

SI Labidi-Galy, E Papp, D Hallberg, N Niknafs… - Nature …, 2017 - nature.com
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer
and has a poor outcome. It has been proposed that fallopian tube cancers may be …

Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation

LE Kandalaft, D Dangaj Laniti, G Coukos - Nature Reviews Cancer, 2022 - nature.com
Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

The origin of ovarian cancer species and precancerous landscape

IM Shih, Y Wang, TL Wang - The American journal of pathology, 2021 - Elsevier
Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …

[HTML][HTML] The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded

RJ Kurman, IM Shih - The American journal of pathology, 2016 - Elsevier
Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a
decade ago, a large number of molecular and histopathologic studies were published that …

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

Cell origins of high-grade serous ovarian cancer

J Kim, EY Park, O Kim, JM Schilder, DM Coffey… - Cancers, 2018 - mdpi.com
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …