Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

Levels of obesity have reached epidemic proportions on a global scale, which has led to
considerable increases in health problems and increased risk of several diseases, including …

Leptin signaling has received considerable attention in the Alzheimer disease (AD) field.
Within the past decade, the peptide hormone has been demonstrated to attenuate tau …

This article brings the choroid plexus into the context of health and disease. It is remarkable
that the choroid plexus, composed by a monolayer of epithelial cells that lie in a highly …

The occurrence of type II diabetes is highly correlated with obesity, although the
mechanisms linking the two conditions are incompletely understood. Leptin is a potent …

Early-life stress (ES) increases the vulnerability to develop psychopathologies and cognitive
decline in adulthood. Interestingly, this is often comorbid with metabolic disorders, such as …

Leptin is a pleiotropic hormone and plays a key role in body weight regulation, energy
homeostasis and lipid store utilization in mammals. In this study, we investigated the effect of …

Maintenance of body weight is fundamental to maintain one's health and to promote
longevity. Nevertheless, it appears that the global obesity epidemic is still constantly …

Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have
reported that tanycytes actively transport circulating leptin across the brain barrier into the …