Therapeutic radionuclides: production and decay property considerations.

WA Volkert, WF Goeckeler, GJ Ehrhardt… - Journal of nuclear …, 1991 - europepmc.org
The development of effective therapeutic radiopharmaceuticals requires careful
consideration in the selection of the radionuclide. The in vivo targeting and clearance …

Radiohalogens for imaging and therapy

MJ Adam, DS Wilbur - Chemical Society Reviews, 2005 - pubs.rsc.org
Radiohalogens play a very important role in radiopharmaceuticals used for medical imaging
(now referred to as molecular imaging) and therapy applications. Development of new …

Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges

TK Nayak, MW Brechbiel - Bioconjugate chemistry, 2009 - ACS Publications
Radioimmunoimaging and therapy has been an area of interest for several decades. Steady
progress has been made toward clinical translation of radiolabeled monoclonal antibodies …

Synthesis and Preliminary Evaluation of 131I-Labeled FAPI Tracers for Cancer Theranostics

H Ma, F Li, G Shen, H Cai, W Liu, T Lan… - Molecular …, 2021 - ACS Publications
As an excellent target for cancer theranostics, fibroblast activation protein (FAP) has become
an attractive focus in cancer research. A class of FAP inhibitors (FAPIs) with a N-(4 …

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity

DB Axworthy, JM Reno, MD Hylarides… - Proceedings of the …, 2000 - National Acad Sciences
A covalent conjugate (NR-LU-10/SA) was prepared between streptavidin (SA) and NR-LU-
10, a mAb that binds an antigen expressed on the surface of most human carcinomas. NR …

[PDF][PDF] A ticket to ride: peptide radiopharmaceuticals

AJ Fischman, JW Babich… - Journal of Nuclear …, 1993 - Soc Nuclear Med
2254 The Journalof NudearMedicine• Vol. 34 • No. 12 • December1993 extremely
diverse; rangingfrom 3 to 5 residues in TRH, enkephalins and bacterial chemoattractant …

Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature

SW Reilly, M Makvandi, K Xu, RH Mach - Organic letters, 2018 - ACS Publications
Access to 211At-and 125I-radiolabeled compounds in excellent RCCs and RCYs was
achieved in just 10 min at room temperature using a Cu catalyst. The reaction conditions are …

Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody

MK Robinson, M Doss, C Shaller, D Narayanan… - Cancer Research, 2005 - AACR
Positron emission tomography (PET) provides an effective means of both
diagnosing/staging several types of cancer and evaluating efficacy of treatment. To date, the …

Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F] fluorobenzoate

G Vaidyanathan, MR Zalutsky - … . Part B. Nuclear medicine and biology, 1992 - Elsevier
Two methods were investigated for the no-carrier-added synthesis of N-succinimidyl 4-[18 F]
fluorobenzoate (S [18 F] FB). The first, an attempted nucleophilic aromatic substitution by [18 …

Development of antibody immuno-PET/SPECT radiopharmaceuticals for imaging of oncological disorders—an update

J Dewulf, K Adhikari, C Vangestel, TVD Wyngaert… - Cancers, 2020 - mdpi.com
Positron emission tomography (PET) and single-photon emission computed tomography
(SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to …