In less than 50 years the field of organ transplantation has transitioned from an experimental
concept to clinical commonplace. Notwithstanding the dramatic improvements in patient and …

“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient
of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This …

Five patients with end-stage renal disease received combined bone marrow and kidney
transplants from HLA single-haplotype mismatched living related donors, with the use of a …

Exciting results reporting that blockade of the CD40/CD40 ligand pathway by monoclonal
antibody against CD40 ligand led to long-term acceptance of renal allografts in monkeys …

We report here the long-term results of HLA-mismatched kidney transplantation without
maintenance immunosuppression (IS) in 10 subjects following combined kidney and bone …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

Background. Experimental and clinical evidence has demonstrated that the establishment of
allogeneic chimerism after bone marrow transplantation may provide donor-specific …

Six patients with renal failure due to multiple myeloma (MM) received simultaneous kidney
and bone marrow transplantation (BMT) from HLA-identical sibling donors following …

Background. Two patients with end-stage renal disease secondary to multiple myelomas
were treated with combined kidney and bone marrow transplantation in an effort to achieve …

Costimulatory blockade with anti-CD154 monoclonal antibody (aCD154) prolongs allograft
survival in nonhuman primates, but has not reliably induced tolerance when used alone. In …