RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in
addition to differential gene expression, thus providing a more complete genetic picture than …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Several mechanisms underlying tumor progression have remained elusive, particularly in
relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial …

Abstract Background Circular RNA (circRNA) is a novel class of noncoding RNAs with
functions in various pathophysiological activities. However, the expression profiles and …

Colorectal cancer (CRC) is a serious public health issue, and it has the leading incidence
and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver …

Advances in genome sequencing have progressed at a rapid pace, with increased
throughput accompanied by plunging costs. But these advances go far beyond faster and …

Transforming growth factor βs (TGF-βs) are closely related ligands that have pleiotropic
activity on most cell types of the body. They act through common heterotetrameric TGF-β …