Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

From basic science and fundamental procedures to the latest advanced techniques in
reconstructive, esthetic, and implant therapy, Newman and Carranza's Clinical …

Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Resolution of inflammation is a finely regulated process mediated by specialized
proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)–derived …

Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …