Background Coronary artery bypass grafting (CABG) is known to improve heart function and
quality of life, while rates of surgery‐related mortality are low. However, delirium and …

Background Postoperative delirium (POD) is common after surgery. As age is a known risk
factor, the increased ageing of the population undergoing surgery emphasizes the …

Background Delirium is a critical postoperative complication in older patients. Based on the
hypothesis that intraoperative dexmedetomidine sedation would lower postoperative …

Introduction The ideal measures to prevent postoperative delirium remain unestablished.
We conducted this systematic review and meta-analysis to clarify the significance of …

Background Aseptic surgical trauma provokes a homeostatic neuroinflammatory response to
promote healing and protect the organism from further injury. When this response is …

Approximately a quarter of a billion people undergo surgery every year hoping that the
operation will alleviate symptoms, cure diseases, and improve quality-of-life. A concern has …

The past decade has witnessed unprecedented medical progress, which has translated into
cardiac surgery being increasingly common and safe. However, complications such as …

Background. A wide variability in the approach towards delirium prevention and treatment in
the critically ill results from the dearth of prospective randomised studies. Methods. We …

Rationale (R)-Ketamine produced beneficial effects in a variety of models of inflammatory
diseases, including low dose of bacterial lipopolysaccharide (LPS)(0.5–1.0 mg/kg)-induced …

Postoperative delirium is associated with increased morbidity, mortality and cost. However,
its neuropathogenesis remains largely unknown, partially owing to lack of animal model (s) …