A survey of gene regulatory networks modelling methods: from differential equations, to Boolean and qualitative bioinspired models

R Barbuti, R Gori, P Milazzo, L Nasti - Journal of Membrane Computing, 2020 - Springer
Abstract Gene Regulatory Networks (GRNs) represent the interactions among genes
regulating the activation of specific cell functionalities, such as reception of (chemical) …

Reaction systems with influence on environment

P Bottoni, A Labella, G Rozenberg - Journal of Membrane Computing, 2019 - Springer
Reaction systems, motivated by the functioning of the living cell, became a novel model of
interactive computation. In this paper, we pursue this line of research. More specifically, we …

[HTML][HTML] Investigating dynamic causalities in reaction systems

R Barbuti, R Gori, F Levi, P Milazzo - Theoretical Computer Science, 2016 - Elsevier
Reaction systems are a qualitative formalism for modeling systems of biochemical reactions
characterized by the non-permanency of the elements: molecules disappear if not produced …

Complexity of the dynamics of reaction systems

A Dennunzio, E Formenti, L Manzoni… - Information and …, 2019 - Elsevier
Reaction systems are discrete dynamical systems inspired by bio-chemical processes,
whose dynamical behaviour is expressed by set-theoretic operations on finite sets. Reaction …

Model checking temporal properties of reaction systems

A Męski, W Penczek, G Rozenberg - Information Sciences, 2015 - Elsevier
This paper defines a temporal logic for reaction systems (rsCTL). The logic is interpreted
over the models for the context restricted reaction systems that generalise standard reaction …

Fixed points and attractors of reaction systems

E Formenti, L Manzoni, AE Porreca - Conference on computability in …, 2014 - Springer
We investigate the computational complexity of deciding the occurrence of many different
dynamical behaviours in reaction systems, with an emphasis on biologically relevant …

[HTML][HTML] Fixed points and attractors of reactantless and inhibitorless reaction systems

R Ascone, G Bernardini, L Manzoni - Theoretical Computer Science, 2024 - Elsevier
Reaction systems are discrete dynamical systems that model biochemical processes in
living cells using finite sets of reactants, inhibitors, and products. We investigate the …

Pure reaction automata

R Ascone, G Bernardini, E Formenti, F Leiter… - Natural Computing, 2024 - Springer
This work introduces the new class of pure reaction automata, as well as a new update
manner, called maximal reactive manner, that can also be applied to standard reaction …

[HTML][HTML] Complexity of model checking for reaction systems

S Azimi, C Gratie, S Ivanov, L Manzoni, I Petre… - Theoretical Computer …, 2016 - Elsevier
Reaction systems are a new mathematical formalism inspired by the living cell and driven by
only two basic mechanisms: facilitation and inhibition. As a modeling framework, they differ …

Dynamic slicing of reaction systems based on assertions and monitors

L Brodo, R Bruni, M Falaschi - International Symposium on Practical …, 2023 - Springer
Abstract Reaction Systems (RSs) are a successful computational framework inspired by
biological systems. RSs can involve a large number of reactions and entities, which makes it …