Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

H Hirao, K Nakamura… - … reviews Gastroenterology & …, 2022 - nature.com
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Hippo signaling in the liver regulates organ size, cell fate, and carcinogenesis

SH Patel, FD Camargo, D Yimlamai - Gastroenterology, 2017 - Elsevier
The Hippo signaling pathway, also known as the Salvador− Warts− Hippo pathway, is a
regulator of organ size. The pathway takes its name from the Drosophila protein kinase …

Transplantation of a human liver following 3 days of ex situ normothermic preservation

PA Clavien, P Dutkowski, M Mueller… - Nature …, 2022 - nature.com
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …

EASL clinical practice guidelines: liver transplantation

European Association for The Study of the Liver - Journal of hepatology, 2016 - Elsevier
The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy
Calne in Cambridge in 1968 [1], only one year after the first successful human liver …

First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched …

P Dutkowski, WG Polak, P Muiesan, A Schlegel… - Annals of …, 2015 - journals.lww.com
Background: Exposure of donor liver grafts to prolonged periods of warm ischemia before
procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft …

Defining benchmarks in liver transplantation: a multicenter outcome analysis determining best achievable results

X Muller, F Marcon, G Sapisochin, M Marquez… - Annals of …, 2018 - journals.lww.com
This multicentric study of 17 high-volume centers presents 12 benchmark values for liver
transplantation. Those values, mostly targeting markers of morbidity, were gathered from …

Validation of the AFP model as a predictor of HCC recurrence in patients with viral hepatitis-related cirrhosis who had received a liver transplant for HCC

A Notarpaolo, R Layese, P Magistri, M Gambato… - Journal of …, 2017 - Elsevier
Background & Aims The AFP model was shown to be superior to the Milan criteria for
predicting hepatocellular carcinoma (HCC) recurrence after liver transplantation in a French …

[HTML][HTML] Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

K Kadono, S Kageyama, K Nakamura, H Hirao, T Ito… - Journal of …, 2022 - Elsevier
Background & Aims Although Ikaros (IKZF1) is a well-established transcriptional regulator in
leukocyte lymphopoiesis and differentiation, its role in myeloid innate immune responses …

Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells

G Pettinato, S Lehoux, R Ramanathan, MM Salem… - Scientific reports, 2019 - nature.com
Despite advances in stem cell research, cell transplantation therapy for liver failure is
impeded by a shortage of human primary hepatocytes (HPH), along with current …

Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation

D Samuel, A Coilly - BMC medicine, 2018 - Springer
Background The results of liver transplantation are excellent, with survival rates of over 90
and 80% at 1 and 5 years, respectively. The success of liver transplantation has led to an …