Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

Simple Summary This study confirms the potential of methylene blue (MB) in treatment
strategies for ovarian cancer. Ovarian cancer cells taken from patients were inserted into …

During the scale‐up of biopharmaceutical production processes, insufficiently predictable
performance losses may occur alongside gradients and heterogeneities. To overcome such …

Patients with unrepaired congenital heart disease (CHD) are prone to pulmonary arterial
hypertension (PAH). The ovine pulmonary arterial smooth muscle cells exposed to …

Hyperosmolality can occur during industrial fed-batch cultivation processes of Chinese
hamster ovary (CHO) cells as highly concentrated feed and base solutions are added to …

We previously demonstrated that most diseases display a form of anabolism due to
mitochondrial impairment: in cancer, a daughter cell is formed; in Alzheimer's disease …

The cancer paradigm is generally based on the somatic mutation model, asserting that
cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) …

Immunoglobulin A (IgA) has been showing potential as a new therapeutic antibody.
However, recombinant IgA suffers from low yield. Supplementation of the medium is an …

Hyperosmolality can occur within the volume of non-ideally mixed large-scale bioreactors
during biopharmaceutical manufacturing. It negatively impacts cellular growth and can …

Recombinant IgA possesses a distinct advantage compared to recombinant IgG which is the
ability to be transcytosed to the mucosal membrane to provide protection against pathogens …