Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

RF Keep, Y Hua, G Xi - The Lancet Neurology, 2012 - thelancet.com
Intracerebral haemorrhage accounts for about 10–15% of all strokes and is associated with
high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been …

Microglial responses after ischemic stroke and intracerebral hemorrhage

RA Taylor, LH Sansing - Journal of Immunology Research, 2013 - Wiley Online Library
Stroke is a leading cause of death worldwide. Ischemic stroke is caused by blockage of
blood vessels in the brain leading to tissue death, while intracerebral hemorrhage (ICH) …

Neuroinflammation after intracerebral hemorrhage

E Mracsko, R Veltkamp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …

[HTML][HTML] Brain edema formation and therapy after intracerebral hemorrhage

Y Wan, KG Holste, Y Hua, RF Keep, G Xi - Neurobiology of disease, 2023 - Elsevier
Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

Mechanism and therapy of brain edema after intracerebral hemorrhage

H Zheng, C Chen, J Zhang, Z Hu - Cerebrovascular diseases, 2016 - karger.com
Background: Intracerebral hemorrhage (ICH) is a subtype of stroke with a severe high
mortality and disability rate and accounts for about 10-15% of all strokes. The oppression …

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target

J Sun, G Nan - International journal of molecular …, 2017 - spandidos-publications.com
Signaling pathways are critical modulators of a variety of physiological and pathological
processes, and the abnormal activation of some signaling pathways can contribute to …

The mitogen-activated protein kinase (MAPK) signaling pathway as a discovery target in stroke

J Sun, G Nan - Journal of Molecular Neuroscience, 2016 - Springer
Protein kinases are critical modulators of a variety of intracellular and extracellular signal
transduction pathways, and abnormal phosphorylation events can contribute to disease …

Pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage

Z Shao, S Tu, A Shao - Frontiers in pharmacology, 2019 - frontiersin.org
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and
morbidity. The resulting hematoma within brain parenchyma induces a series of adverse …