[HTML][HTML] Extracellular matrix and its therapeutic potential for cancer treatment
J Huang, L Zhang, D Wan, L Zhou, S Zheng… - … and Targeted Therapy, 2021 - nature.com
The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …
crucial roles, including mechanical support, modulation of the microenvironment, and a …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Hyaluronic acid: A key molecule in skin aging
E Papakonstantinou, M Roth… - Dermato …, 2012 - Taylor & Francis
Skin aging is a multifactorial process consisting of two distinct and independent
mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and …
mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and …
[HTML][HTML] Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities
CH Park, SY Min, HW Yu, K Kim, S Kim, HJ Lee… - International Journal of …, 2020 - mdpi.com
Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
Hyaluronan in wound healing: rediscovering a major player
KL Aya, R Stern - Wound repair and regeneration, 2014 - Wiley Online Library
Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …
Chemical synthesis of glycosaminoglycans
M Mende, C Bednarek, M Wawryszyn, P Sauter… - Chemical …, 2016 - ACS Publications
Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …
essential biological cell processes, as well as in many courses of diseases. Because of the …
[HTML][HTML] Transmembrane pickets connect cyto-and pericellular skeletons forming barriers to receptor engagement
Phagocytic receptors must diffuse laterally to become activated upon clustering by
multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane …
multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane …
Placental tissues as biomaterials in regenerative medicine
A Roy, M Mantay, C Brannan… - BioMed Research …, 2022 - Wiley Online Library
Placental tissues encompass all the tissues which support fetal development, including the
placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has …
placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has …
Hyaluronan in tissue injury and repair
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …