Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …

The relation between obesity and osteoarthritis (OA) development has been traditionally
explained as consequence of the excessive joint effort derived of overweight. However, in …

Evidence suggests a unique association between bone aging and neurodegenerative/
cerebrovascular disorders. However, the mechanisms underlying bone‐brain interplay …

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and cartilage degradation. Dendrobine (DEN) is reported to inhibit inflammation and …

In addition to reducing fracture risk, zoledronic acid has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

Background Osteoarthritis (OA) is one of degenerative-related arthritis, which can be
aggravated by low-grade synovitis. It is known that arachidonic acid (AA) dysmetabolism …

Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the
mechanical loading environment. However, it is unclear whether the signals of bone cells in …

Lipid metabolic dysregulation and liver inflammation have been reported to be associated
with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain unclear …

Osteoarthritis (OA) is a complex disease characterized by cartilage degeneration and
persistent pain. Prostaglandin E2 (PGE2) plays a significant role in OA inflammation and …

Periprosthetic osteolysis is the leading cause of prosthesis failure and subsequent total joint
revision. Wear particles produced by prosthetic materials are the main biological factors that …