Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
D Blum, S Torch, N Lambeng, MF Nissou… - Progress in …, 2001 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …
Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis
AG Kanthasamy, M Kitazawa, A Kanthasamy… - Neurotoxicology, 2005 - Elsevier
Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder
strongly associated with environmental chemical exposures. Recent epidemiological data …
strongly associated with environmental chemical exposures. Recent epidemiological data …
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
WA Holtz, KL O'Malley - Journal of Biological Chemistry, 2003 - ASBMB
Genes associated with Parkinson's disease (PD) have suggested a role for ubiquitin-
proteasome dysfunction and aberrant protein degradation in this disorder. Inasmuch as …
proteasome dysfunction and aberrant protein degradation in this disorder. Inasmuch as …
Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
Nurr1, a transcription factor belonging to the nuclear receptor family, is essential for the
generation of midbrain dopamine (DA) cells during embryonic development. Nurr1 …
generation of midbrain dopamine (DA) cells during embryonic development. Nurr1 …
Apoptotic molecules and MPTP-induced cell death
A Nicotra, SH Parvez - Neurotoxicology and teratology, 2002 - Elsevier
MPTP-induced neurotoxicity is one of the experimental models most commonly used to
study the pathogenesis of Parkinson's disease (PD). MPTP administered in vivo to mice …
study the pathogenesis of Parkinson's disease (PD). MPTP administered in vivo to mice …
Caspase-dependent and-independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment
BS Han, HS Hong, WS Choi, GJ Markelonis… - Journal of …, 2003 - Soc Neuroscience
Although the cause of neuronal death in Parkinson's disease (PD) is mainly unknown,
growing evidence suggests that both apoptotic and non-apoptotic death may occur in PD …
growing evidence suggests that both apoptotic and non-apoptotic death may occur in PD …
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function
K Eldeeb, S Leone-Kabler, AC Howlett - Journal of basic and clinical …, 2016 - degruyter.com
Background: CB1 cannabinoid receptors (CB1Rs) stimulate Gi/o-dependent signaling
pathways. CB1R-mediated cAMP increases were proposed to result from Gs activation, but …
pathways. CB1R-mediated cAMP increases were proposed to result from Gs activation, but …
Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cδ
RL Cunningham, A Giuffrida, JL Roberts - Endocrinology, 2009 - academic.oup.com
Aged men have a greater incidence of Parkinson's disease (PD) than women. PD is a
neurodegenerative condition associated with the loss of dopamine neurons in the …
neurodegenerative condition associated with the loss of dopamine neurons in the …
Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in …
T Hashimoto, K Nishi, J Nagasao, S Tsuji, K Oyanagi - Brain research, 2008 - Elsevier
A study was conducted to clarify the effects of magnesium (Mg) administration in a rat
Parkinson disease (PD) model involving culture of ventral mesencephalic–striatal cells with …
Parkinson disease (PD) model involving culture of ventral mesencephalic–striatal cells with …
Polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress plays a role in dopaminergic cell injury
DW Lee, LA Opanashuk - Neurotoxicology, 2004 - Elsevier
Oxidative stress (OS) is thought to participate in the pathogenesis of neurodegenerative
disorders, including Parkinson's disease (PD). Excessive reactive oxygen species (ROS) …
disorders, including Parkinson's disease (PD). Excessive reactive oxygen species (ROS) …