Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D
AV Krishnan, D Feldman - Annual review of pharmacology and …, 2011 - annualreviews.org
Calcitriol, the hormonally active form of vitamin D, is being evaluated in clinical trials as an
anti-cancer agent. Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro …
anti-cancer agent. Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro …
Regulation of inflammation in cancer by eicosanoids
Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …
Obesity and cancer: mechanistic insights from transdisciplinary studies
EH Allott, SD Hursting - Endocrine-related cancer, 2015 - erc.bioscientifica.com
Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …
significance, including cancer. Herein, we summarize epidemiologic and preclinical …
The role of vitamin D in cancer prevention and treatment
AV Krishnan, DL Trump… - Rheumatic Disease …, 2012 - rheumatic.theclinics.com
Calcitriol (1, 25-dihydroxyvitamin D3), the biologically most active form of vitamin D,
maintains calcium homeostasis through its actions in intestine, bone, kidneys, and the …
maintains calcium homeostasis through its actions in intestine, bone, kidneys, and the …
Prostate carcinogenesis and inflammation: emerging insights
GS Palapattu, S Sutcliffe, PJ Bastian, EA Platz… - …, 2005 - academic.oup.com
Prostate cancer remains a significant health concern for men throughout the world. Recently,
there has developed an expanding multidisciplinary body of literature suggesting a link …
there has developed an expanding multidisciplinary body of literature suggesting a link …
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin
Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a
wide array of pharmacologic effects. The present study was aimed at unraveling the …
wide array of pharmacologic effects. The present study was aimed at unraveling the …
Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages
L Staurengo-Ferrari, S Badaro-Garcia… - Frontiers in …, 2019 - frontiersin.org
Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …
treat painful and inflammatory diseases, there is still a need for effective and potent …
Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone
Calcium homeostasis is a tightly regulated process involving the co-ordinated efforts of the
skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis …
skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis …
Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I–induced signaling in an autochthonous mouse model of prostate cancer
We earlier demonstrated that oral infusion of green tea polyphenols inhibits development
and progression of prostate cancer in transgenic adenocarcinoma of the mouse prostate …
and progression of prostate cancer in transgenic adenocarcinoma of the mouse prostate …
Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory
Cancer chemoprevention is a process of using either natural or synthetic compounds to
reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2) …
reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2) …