Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

The phospholipase A2 (PLA2) superfamily consists of a broad range of enzymes defined by
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …

Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily
through the action of cytosolic phospholipase A2-α. Three major downstream pathways …

The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …

Abstract The phospholipase A 2 (PLA 2) superfamily consists of many different groups of
enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different …

ABSTRACT Phospholipase A 2 (PLA 2) plays crucial roles in diverse cellular responses,
including phospholipid digestion and metabolism, host defense and signal transduction …

The endoplasmic reticulum (ER) in animal cells is an extensive, morphologically continuous
network of membrane tubules and flattened cisternae. The ER is a multifunctional organelle; …