Voltage-gated Na+ channels mediate the rapid upstroke of the action potential in excitable
tissues. Nav1. 5, encoded by the SCN5A gene, is the predominant isoform in the heart …

The SCN5A gene encodes the alpha-subunit of the Na v 1.5 ion channel protein, which is
responsible for the sodium inward current (I Na). Since 1995 several hundred mutations in …

Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We
previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in …

During the past decade, Nav1. 5, the main voltage-gated Na+ channel in the heart, has been
shown to be involved in many cardiac diseases. Genetic variants in the gene SCN5A …

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for
more than 15% of strokes. Mutations in cardiac sodium channel α, β1 and β2 subunit genes …

The cardiac sodium channel Na v 1.5 is essential for the physiological function of the heart
and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we …

As a major cardiac voltage-gated sodium channel isoform in the heart, the Nav1. 5 channel
is essential for cardiac action potential initiation and subsequent propagation throughout the …

Na v 1.5, the pore-forming α subunit of the cardiac voltage-gated Na+ channel complex, is
required for the initiation and propagation of the cardiac action potential. Mutations in Na v …

Genetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated
sodium channel Nav1. 5 are associated with various diseases, including long QT syndrome …

Background The cardiac sodium channel Na v 1.5 is essential for the physiological function
of the heart and causes cardiac arrhythmias and sudden death when mutated. Many …