Quantitative proteomic analysis of histone modifications
Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …
including altering the physical properties of nucleosomes by neutralization of charge via …
Understanding RNA modifications: the promises and technological bottlenecks of the 'epitranscriptome'
The discovery of mechanisms that alter genetic information via RNA editing or introducing
covalent RNA modifications points towards a complexity in gene expression that challenges …
covalent RNA modifications points towards a complexity in gene expression that challenges …
Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …
developmentally regulated regions of the genome dynamically associated with the nuclear …
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
Epigenetic dysregulation is an emerging hallmark of cancers. We developed a high-
information-content mass spectrometry approach to profile global histone modifications in …
information-content mass spectrometry approach to profile global histone modifications in …
Combinations of histone post-translational modifications
Histones are essential proteins that package the eukaryotic genome into its physiological
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
The top‐down, middle‐down, and bottom‐up mass spectrometry approaches for characterization of histone variants and their post‐translational modifications
Epigenetic regulation of gene expression is, at least in part, mediated by histone
modifications. PTMs of histones change chromatin structure and regulate gene transcription …
modifications. PTMs of histones change chromatin structure and regulate gene transcription …
Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man
It is striking that within a eukaryotic nucleus, the genome can assume specific
spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is …
spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is …
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
A quantitative atlas of histone modification signatures from human cancer cells
Background An integral component of cancer biology is the understanding of molecular
properties uniquely distinguishing one cancer type from another. One class of such …
properties uniquely distinguishing one cancer type from another. One class of such …
Multiplexed, scheduled, high-resolution parallel reaction monitoring on a full scan QqTOF instrument with integrated data-dependent and targeted mass spectrometric …
Recent advances in commercial mass spectrometers with higher resolving power and faster
scanning capabilities have expanded their functionality beyond traditional data-dependent …
scanning capabilities have expanded their functionality beyond traditional data-dependent …