In recent years, N-heterocyclic carbenes (NHCs) have established themselves as a
masterful and promising type of organocatalyst for the speedy construction of medicinally …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

Amides are among the most fundamental functional groups and essential structural units,
widely used in chemistry, biochemistry and material science. Amide synthesis and …

The use of functionalized aldimines has been demonstrated as newly structural 1, 4‐dipole
precursors under carbene catalysis. More importantly, enantiodivergent organocatalysis has …

N-Heterocyclic carbene (NHC)-catalyzed [3+ 3] annulation of thioamides with modified enals
allowing the enantioselective synthesis of functionalized 1, 3-thiazin-4-ones is reported. The …

A catalytic asymmetric vinylogous Mannich/annulation/acylation reaction of 2‐ethylidene 1,
3‐indandiones with isatin N‐Boc ketimines has been developed, which furnished a series of …

Spiroannulation reactions are fundamental and invaluable for the synthesis of spirocyclic
compounds. Presented herein are novel cascade reactions of aryl azomethine imines with …

Indanone-containing compounds are very important components of various natural
products, chemical drugs, agrochemicals and functionalized material fields. 1, 3 …

A variety of γ-keto-β-silyl esters and amides, most with extremely high enantioselectivities,
were efficiently prepared via a carbene-catalyzed formal [4+ 2] annulation followed by ring …

A convenient synthetic protocol for regioselective and diastereoselective construction of
complex dispiro-indanone-fluorenone-oxindole motifs was developed by the base-promoted …