Age-related macular degeneration
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
[HTML][HTML] The progression of geographic atrophy secondary to age-related macular degeneration
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD)
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …
[HTML][HTML] C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial
GJ Jaffe, K Westby, KG Csaky, J Monés, JA Pearlman… - Ophthalmology, 2021 - Elsevier
Purpose The complement pathway may play a key role in the pathogenesis of age-related
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial
AM Khanani, SS Patel, G Staurenghi, R Tadayoni… - The Lancet, 2023 - thelancet.com
Background Geographic atrophy is an advanced form of dry age-related macular
degeneration that can lead to irreversible vision loss and high burden of disease. We aimed …
degeneration that can lead to irreversible vision loss and high burden of disease. We aimed …
[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …
is a major cause of blindness. Even while central visual acuity remains relatively well …
Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3
Purpose To develop consensus terminology and criteria for defining atrophy based on OCT
findings in the setting of age-related macular degeneration (AMD). Design Consensus …
findings in the setting of age-related macular degeneration (AMD). Design Consensus …
Automated grading of age-related macular degeneration from color fundus images using deep convolutional neural networks
Importance Age-related macular degeneration (AMD) affects millions of people throughout
the world. The intermediate stage may go undetected, as it typically is asymptomatic …
the world. The intermediate stage may go undetected, as it typically is asymptomatic …
[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …
because many diseases affect the retina and choroid leading to impaired vision or …
Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: classification of atrophy meeting report 4
Purpose To describe the defining features of incomplete retinal pigment epithelium (RPE)
and outer retinal atrophy (iRORA), a consensus term referring to the OCT-based anatomic …
and outer retinal atrophy (iRORA), a consensus term referring to the OCT-based anatomic …
The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …