In vivo imaging technologies have emerged as a powerful tool for both fundamental
research and clinical practice. In particular, luminescence imaging in the tissue-transparent …

This review describes the diffusion model for light transport in tissues and the medical
applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue …

Time-correlated single photon counting (TCSPC) is based on the detection of single photons
of a periodic light signal, measurement of the detection time of the photons, and the build-up …

The field of biomedical optics has matured rapidly over the last decade and is poised to
make a significant impact on patient care. In particular, wide-field (typically> 5 cm), planar …

A recent development in biomedical imaging is the non-invasive mapping of molecular
events in intact tissues using fluorescence. Underpinning to this development is the …

Fluorescence sampling of cellular function is widely used in all aspects of biology, allowing
the visualization of cellular and sub-cellular biological processes with spatial resolutions in …

Diffuse optical tomography (DOT) is an ongoing medical imaging modality in which tissue is
illuminated by near-infrared light from an array of sources, the multiply-scattered light which …

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

We present quantitative optical images of human breast in vivo. The images were obtained
by using near-infrared diffuse optical tomography (DOT) after the administration of …

The development of hybrid optical tomography methods to improve imaging performance
has been suggested over a decade ago and has been experimentally demonstrated in …