Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …

Ramachandran plots report the distribution of the (ϕ, ψ) torsion angles of the protein
backbone and are one of the best quality metrics of experimental structure models. Typically …

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …

AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

AMPA receptors mediate fast excitatory neurotransmission and are critical for CNS
development and function. Calcium-permeable subsets of AMPA receptors are strongly …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …