Current understanding of the right ventricle structure and function in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular
(RV) afterload and RV remodeling. PAH results in altered RV structure and function at …
(RV) afterload and RV remodeling. PAH results in altered RV structure and function at …
Pathophysiology of acute and chronic right heart failure
RA Thandavarayan, KR Chitturi… - Cardiology …, 2020 - cardiology.theclinics.com
Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle (RV)
caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction leading …
caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction leading …
Angiotensin receptor‐neprilysin inhibition attenuates right ventricular remodeling in pulmonary hypertension
D Sharifi Kia, E Benza, TN Bachman… - Journal of the …, 2020 - Am Heart Assoc
Background Pulmonary hypertension (PH) results in increased right ventricular (RV)
afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual acting drug …
afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual acting drug …
Right ventricular architectural remodeling and functional adaptation in pulmonary hypertension
EA Mendiola, D da Silva Gonçalves Bos… - Circulation: Heart …, 2023 - Am Heart Assoc
Background: Global indices of right ventricle (RV) function provide limited insights into
mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV …
mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV …
An image-driven micromechanical approach to characterize multiscale remodeling in infarcted myocardium
Myocardial infarction (MI) is accompanied by the formation of a fibrotic scar in the left
ventricle (LV) and initiates significant alterations in the architecture and constituents of the …
ventricle (LV) and initiates significant alterations in the architecture and constituents of the …
Simulation of the 3D hyperelastic behavior of ventricular myocardium using a finite-element based neural-network approach
High-fidelity cardiac models using attribute-rich finite element based models have been
developed to a very mature stage. However, such finite-element based approaches remain …
developed to a very mature stage. However, such finite-element based approaches remain …
Right ventricular myocardial mechanics: Multi-modal deformation, microstructure, modeling, and comparison to the left ventricle
The right ventricular myocardium, much like the rest of the right side of the heart, has been
consistently understudied. Presently, little is known about its mechanics, its microstructure …
consistently understudied. Presently, little is known about its mechanics, its microstructure …
A contemporary look at biomechanical models of myocardium
Understanding and predicting the mechanical behavior of myocardium under healthy and
pathophysiological conditions are vital to developing novel cardiac therapies and promoting …
pathophysiological conditions are vital to developing novel cardiac therapies and promoting …
Oxidative stress and its implications in the right ventricular remodeling secondary to pulmonary hypertension
M Mikhael, C Makar, A Wissa, T Le, M Eghbali… - Frontiers in …, 2019 - frontiersin.org
Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by increased
pulmonary artery pressures. Long standing pulmonary arterial pressure overload leads to …
pulmonary artery pressures. Long standing pulmonary arterial pressure overload leads to …
Untangling the mechanisms of pulmonary arterial hypertension-induced right ventricular stiffening in a large animal model
Pulmonary hypertension (PHT) is a devastating disease with low survival rates. In PHT,
chronic pressure overload leads to right ventricle (RV) stiffening; thus, impeding diastolic …
chronic pressure overload leads to right ventricle (RV) stiffening; thus, impeding diastolic …