Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …

Liver transplantation is the accepted treatment for patients with acute liver failure and liver-
based metabolic disorders. However, donor organ shortage and lifelong need for …

Liver regeneration is a complex and unique process. When two-thirds of a mouse liver is
removed, the remaining liver recovers its initial weight in approximately 10 days. The …

Proton pump inhibitors (PPIs) may be a risk factor for hepatic encephalopathy (HE) in
patients with cirrhosis, possibly through translocation of gut bacteria, which can also lead to …

Background Liver, as a vital organ, is responsible for a wide range of biological functions to
maintain homeostasis and any type of damages to hepatic tissue contributes to disease …

The liver is a very complex organ that ensures numerous functions; it is thus susceptible to
multiple types of damage and dysfunction. Since 1983, orthotopic liver transplantation (OLT) …

Donor organ shortage is the main limitation to liver transplantation as a treatment for end-
stage liver disease and acute liver failure. Liver regenerative medicine may in the future offer …

The ability to precisely modify human genes has been made possible by the development of
tools such as meganucleases, zinc finger nucleases, TALENs, and CRISPR/Cas. These now …

Liver transplantation is the only effective therapy for patients with decompensated cirrhosis
and fulminant liver failure. However, due to a shortage of donor livers and complications …

The liver is one of the most studied organs of the human body owing to its central role in
xenobiotic and drug metabolism. In recent decades, extensive research has aimed at …