PPARs and microbiota in skeletal muscle health and wasting

R Manickam, K Duszka, W Wahli - International journal of molecular …, 2020 - mdpi.com
Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy
production and has the capacity to remodel itself in response to exercise and fasting …

Peroxisome proliferator-activated receptors and caloric restriction—common pathways affecting metabolism, health, and longevity

K Duszka, A Gregor, H Guillou, J König, W Wahli - Cells, 2020 - mdpi.com
Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …

[HTML][HTML] Thiazolidinediones as anti-cancer agents

C Blanquicett, J Roman, CM Hart - Cancer therapy, 2008 - ncbi.nlm.nih.gov
The PPAR-gamma (PPAR-γ) activating thiazolidinedione (TZD) medications are a class of
drugs used to improve lipid and glucose metabolism in type-2 diabetes. In addition to their …

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and …

H Geng, J Chen, K Tu, H Tuo, Q Wu, J Guo… - Journal of …, 2023 - Springer
Background Hepatic ischemia-reperfusion injury (HIRI) is a pathophysiological process
during liver transplantation, characterized by insufficient oxygen supply and subsequent …

Peroxisome proliferator-activated receptors and the hallmarks of cancer

N Wagner, KD Wagner - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Peroxisome proliferator‐activated receptors as therapeutic target for cancer

Y Wang, F Lei, Y Lin, Y Han, L Yang… - Journal of Cellular and …, 2024 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs) are transcription factors belonging to
the nuclear receptor family. There are three subtypes of PPARs, including PPAR‐α, PPAR …

PPARγ modulates long chain fatty acid processing in the intestinal epithelium

K Duszka, M Oresic, C Le May, J König… - International journal of …, 2017 - mdpi.com
Nuclear receptor PPARγ affects lipid metabolism in several tissues, but its role in intestinal
lipid metabolism has not been explored. As alterations have been observed in the plasma …

Superpulsed laser irradiation increases osteoblast activity via modulation of bone morphogenetic factors

S Saracino, M Mozzati, G Martinasso… - Lasers in Surgery …, 2009 - Wiley Online Library
Abstract Background and Objective Laser therapy is a new approach applicable in different
medical fields when bone loss occurs, including orthopedics and dentistry. It has also been …

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Y Xiao, S Cai, L Liu, X Yang, J Yun - Cancer management and …, 2018 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism.
Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of …